How we might address the issue of chronic tumour hypocrisy and reoxygenation in

Question

How we might address the issue of chronic tumour hypocrisy and reoxygenation in patients in terms of I) per treatment assays, in vivo measurements and/or imaging. II) adjuvant therapies(drugs or other agents). iii) overall radiotherapy time IV) fractionational schedule V) radiation dose distribution across the tumour.
In terms of overall time and fractionation schedule, how will these impact on the other four R's of radiology?
overall radiotherapy time is the number of weeks radiotherapy will be going on and fractionational schedule means the amount of dose per fraction delivered over a certain number of weeks and a certain number of days per week.

Explanation / Answer

Cancer can be cured totally or it may became chronic(ongoing) like other diseases such as diabetes or heart disease.

Certain types of cancer like ovarian cancer, chronic leukemias and some lymphomas can become chronic.

It spreads or have come back in other parts of the body.

The cancer may be controlled with treatment by which it might seems to go away or stay at tge sme place.

It may not grow or spread as long as you are getting treatment.

Chronic lymphocytic leukemia cells depend on microenvironmental interactions for proliferation and survival that are at least partially mediated through B cell receptor (BCR) signaling.

Ibrutinib a Bruton's tyrosine kinase inhibitor, disrupts BCR signaling and leads to the egress of tumor cells from the microenvironment.

While on-target effects on CLL cells are well defined the impact on the microenvironment is less well studied.

Therefore we sought to characterize the in vivo effects of ibrutinib on tumor microenvironment.

Adjuvant cancer treatment given after the primary treatment to lower the risk of cancer to come back.

This therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy or biological therapy.

Adjuvant pain medications can include antipressants, antiseizure medications, muscle relaxants , sedatives or anti-axiety medications and botulinum toxin.

Adjuvant is actually given to modify the effect of other agents and to boost immune response.

There are some side effects of it:

There is non adjuvant therapy also in contrast to adjuvant therapy which is given before the main treatment.

For example removal of breats in breast cancer is considered as neoadjuvant chemotherapy.

The prescribed radiation dose should be administered within a specific time.

Unplanned treatment interruptions results in prolongation of overall treatment.

Breast cancer and prostate cancer are the most common cancers diagnosed in women and men.

Radiotherapy is used extensively in the treatment of both.

In vitro data suggest that tumors in tge breast and prostate have unique properties that makes a hypofractionated radiotherapy treatment schedule advantageous in terms of therapeutic index.

This can improve patient's outcome.

Radiation dose distribution is necessary in functional heart regions and breast cancer radiotherapy.

Is is to analyse the distribution of individually-determined radiation dosebto tge heart and its functional sub-structures after radiotherapy in breast cancer patients.

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