After gathering all data and completing the data table for activity 4, describe

Question

After gathering all data and completing the data table for activity 4, describe which patient exhibits the signs of Addison’s disease. Explain, specifically, the physiological mechanism linking the symptoms of Addison’s disease with the lab results shown.

Clean Column Cortisol ACTH HPLC Detector 0.00 HPLC Column 2 3 4 5 5 10 15 20 HPLC Injector Clean Patient Samples Cortisol ACTH (pg/ml) 16.33 12.32 85.16 102.61 18.91 High Low High Low Low Low High High LOW Patient (mcg/dl) 3.81 39.47 46.83 3.40 49.25 Low High High Low High Record Data 2 3 4 5

Explanation / Answer

Answer:- Patient 4 with low cortisol ( 3.40 mcg/dl) and high ACTH ( 102.61 pH/ml)

Explanation:- Addisons disease is a hormonal disorder mostly occurs when any damage to adrenal gland resulting in low production of the hormone cortisol and also characterised as primary adrenal insufficiency.Cortisol belongs to a class of hormones called glucocorticoids and helps regulate many metabolism as well as the body respond to stress. Cortisol is regulated by the brains hypothalamus and the pituitary gland. Firstly the hypothalamus releases corticotropin-releasing hormone (CRH), which signals the pituitary gland to secrete ACTH. Here ACTH stimulates the adrenal glands to produce cortisol.Cortisol then signals back to both the pituitary gland and hypothalamus to decrease these stimulating hormones. Therefore low level of cartisol triggers production of high ACTH. However here in Addison’s disease, there is no more production of cartisol and ACTH secretion continues results in high ACTH concentration.

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