Table 1 (below) shows the concentrations of major ions in the intracellular flui

Question

Table 1 (below) shows the concentrations of major ions in the intracellular fluid (cytoplasm) and extracellular fluid of the squid giant axon. In(mW) 50 400 60 270 ION TYPE Out (mM) 440 20 560 very few to none Na+ CI- organic anions Suppose this squid giant axon at rest is 20 times more permeable to K+ as it is to Na+. Assume that K+ permeability is at its maximum and that the cell is not permeable to Cl-. Using the simplified version of the Goldman equation (below), calculate the resting membrane potential. Choose the answer below that best matches your calculation (+/- 1 mV) yn = EK,Na = 58 log-PKTK+p + Pya [Na+]i

Explanation / Answer

Vm = 58 log (20 P × 20 ÷ 20 P × 400) + (P × 440 ÷ P × 50)

Vm = 58 log ( 20÷ 400) + (440÷50)

Vm = 58 log (0.05 + 8.8)

Vm = -54.922 mV

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