60: You are performing a I-clamp recording of GABAergic IPSPs in a neuron restin

Question

60: You are performing a I-clamp recording of GABAergic IPSPs in a neuron resting at -70 mV. The reversal potential of the GABAergic events is -60 mV. Therefore, the IPSP is:

A. inward

B. outward

C. neutral

D. depolarizing

E. hyper polarizing

61: You are recording GABAergic IPSCs in Cl-symmetric conditions, at a holding potential of -70 mV. Under these conditions, the recorded IPSCs are:

A. inward

B. outward

C. neutral

D. depolarizing

E. hyperpolarizing

62: You are recording NMDA currents (E=0) while voltage-clamping a neuron at +40 mV. The events are:

A. inward

B. outward

C. neutral

D. depolarizing

E. hyperpolarizing

63: If you wanted to record glutamatergic EPSPs as depolarizing events, where would you hold your cell?

A. -70 mV

B. 0 mV

C. 40 mV

D. -70pA

E. 40 pA

Explanation / Answer

60. D. Since the membrane potential is becoming more positive (less negative), the IPSP is depolarizing in nature.

61.E under such conditions, the neuron will get hyperpolarized ie mire negative than -70mV

62. C. The neuron reaches max depolarization at -30 to -40mV. This this is a neutral state

63. A Since the resting Potential of the cell is -70mV, we can observe any fluctuations in potential by holding it at that position

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