Model 4: A Synapse 11. Based on the model, would you consider the synaptic knob

Question

Model 4: A Synapse 11. Based on the model, would you consider the synaptic knob to be part of the pre-synaptic or post-synaptic cell? 1. Action potential travels down axon towards synaptic knob 2. Action potential causes voltage-gated Ca channels to open Synaptic Knob 12. What causes the voltage-gated calcium channels to open? Voltage-gated Ca channel Ca 3. Calcium causes exocytosis of neurotransmitter 4. Neurotransmitter e binds to stimulus gated Synaptic cleftchannel and causes it to 13. What is the effect open. of calcium ions entering the cell? Post-synaptic cell 14. What kind of channel opens in response to binding a neurotransmitter? Application If the channel in the post-synaptic cell were a K+ channel, would opening it stimulate or inhibit the post-synaptic cell? 15.

Explanation / Answer

11. The synapse is located at the end of each axonal end branch. Here the end branch forms a small button-like knob . so a part of pre synaptic cell

12.Voltage-gated Ca2+ channels located in the membrane of Purkinje cell dendrites are activated by the climbing-fiber-mediated EPSP.

13.. Influx ofcalcium ions through selective voltagesensitive ion channels (calcium channels) plays a key role to link the action potential to the triggering of secretory vesicle discharge.

14. Voltage gated ion channels open and close in response to neurotransmitter.

15. k+ channel  Reopen,this allows positive ions to diffuse to the exterior, which causes increased negativity inside the neuron this is inhibitory.

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