Which is statement is TRUE? Phosophorylation of a receptor tyrosine kinase makes

Question

Which is statement is TRUE?

Phosophorylation of a receptor tyrosine kinase makes the receptor a transcription factor which migrates to the nucleus

The Jak-STAT pathway requires a phophorylation step but the receptor tyrosine kinase pathway does not

Gbeta and Ggamma form the extracellular binding pocket for a ligand which activates the G-protein pathway

Prostaglandin production requires the activity of the cyclooxygenase enzyme

G-proteins are active when Galpha is bound to GDP

Phosophorylation of a receptor tyrosine kinase makes the receptor a transcription factor which migrates to the nucleus

The Jak-STAT pathway requires a phophorylation step but the receptor tyrosine kinase pathway does not

Gbeta and Ggamma form the extracellular binding pocket for a ligand which activates the G-protein pathway

Prostaglandin production requires the activity of the cyclooxygenase enzyme

G-proteins are active when Galpha is bound to GDP

Explanation / Answer

E. G-proteins are active when G alpha is bound to GDP ion

Explanation: The three subunits of heterotrimer G-proteins are G, G, and G subunits. G subunit determines the receptors to which a G-protein trimer binds to . At rest, the G subunit is GDP bound. Activation of G-proteins takes place through exchange of GDP for GTP.

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