Assuming “aging” of the acetylcholinesterase enzyme has not yet occurred, could

Question

Assuming “aging” of the acetylcholinesterase enzyme has not yet occurred, could 2-PAM reverse the paralysis of respiratory muscles? A) yes B) no

Another type of drug that is used in organophosphate poisoning is benzodiazepines– these drugs increase the effects of GABA. Dr. Sage reminds you that seizures can occur with organophosphate poisoning. Answer this question in a general way. Knowing what you know about GABA, could a drug that increases the effects of GABA make sense to use in this patient with organophosphate poisoning to prevent seizures? A) no B) yes

The military nerve gas sarin has been used during military conflicts. Sarin causes inhibition of the enzyme that breaks down ACh. If the effect of sarin you are seeing is the result of stimulation of muscarinic receptors in the iris, what should you expect pupils to look like? A) constricted B) dilated

Explanation / Answer

1. Yes.Pralidoxime has an important role in reversing paralysis of the respiratory muscles but due to its poor blood–brain barrier penetration, it has little effect on centrally-mediated respiratory depression.

2. Yes.diazepam prevents and treats convulsions produced by OPs and may prevent the late effects caused by damage to the central nervous system induced by such convulsions. Consequently, the use of diazepam is an important part of the treatment regimen of severe OP poisoning as it prevents, or at least reduces the duration of, convulsions.

3. Constricted.

sarin attacks the nervous system by interfering with the degradation of the neurotransmitter acetylcholine at neuromuscular junctions. Death will usually occur as a result of asphyxia due to the inability to control the muscles involved in breathing function.

Initial symptoms following exposure to sarin are a runny nose, tightness in the chest and constriction of the pupils.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.