RIGOR MORTIS (MUSCLE CONTRACTION) Nurse Emma called for a code-blue from Mrs. We
ID: 3510627 • Letter: R
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RIGOR MORTIS (MUSCLE CONTRACTION) Nurse Emma called for a code-blue from Mrs. Weitzel's room. Several nurses and doctors rushed into the room with a crash cart. Mrs. Weitzel was not breathing, was ashen in color, and was very cold. The emergency team could not find a pulse or a heartbeat, and they could not detect respiration. On closer examination, the doctor found that every joint in her body was stiff Just then Mrs. Weitzel's son, Josh, entered the room. Josh had come to visit his mother and was shocked to see so many people in her room. He couldn't believe his ears when the doctor declared his mother deceased. Josh remembered that Emma had been taking care of her and demanded that she explain what happened Nurse Emma told Josh that she entered the room half an hour ago and let Mrs. Weitzel sleep while she tidied up. As Emma had approached the side of the bed, Mrs. Weitzel had suddenly moved her leg. Upon further investigation Emma noticed that Mrs. Weitzel was not breathing. When we heard this Josh was infuriated. He insisted that Emma was negligent because she was standing right there while his mother died. Later that week a board of inquiry convened at the insistence of Josh's lawyer. Emma was accused of negligence in the care of her patient, but you know this is not the truth. Help explain to Josh what happened in that hospital room. Give some background by explaining the chain of events that occur in muscle contractions I. What is the extemal stimulus on the skeletal muscle fiber that signals contraction and where does it come from? a. Which protein blocks the myofilaments, actin and myosin, from interacting to prevent a contraction? b. c. Where is calcium stored in the skeletal muscle fiber? Modified from : Braude, S, Goran, D., and Miceli, A., Case Studies for Understanding the Page 1 Human Body 2nd ed. Jones& Bartlett Learning: Sudbury, MA (2012).Explanation / Answer
muscles contraction involves sequence of events which is initiated by CNS or central Nervous System. This contraction is lead by reflex activity from spinal cord. In spinal cord motor neuron become activated and send an action potential in the ventral root of spinal cord.This action potential is conveyed to motor end plate where it releases acetylocholine into the synaptic cleft of muscle fibres,
This causes change in the resting potential and again initiate action potential which spread in both direction in muscle fiber. From the surface of muscle fiber this action potential spread inside through transverse tubule. When transverse tubule touches sarcoplasmic reticulum then it release ca++ ions. This calcium ions lead myosin molecules to grab their way along thin filaments and thus create driving force for the muscle contraction.
A. Skeleton muscles comes under the category of striated muscles. Skeleton muscles are stimulated by Motor neuron which emerged from spinal cord. Skeleton muscles are consist of multiple muscles fibers. These fibres are slow and fast twitch muscles.
Skeleton muscles contains numerous muscles fibres. When signals of nervous system reaches through these neuromuscular junctions then motor neuron realeases chemical messsage called acetylcholine.
B. The protein which block the attachment of myosin head s to actin is tropomyosin. It is two stranded alpha helical coiled protein. It regulate the function of actin filament in Muscles cells.It inhibit the muscle contraction by blocking the interaction of actin and myosin
Tropomyosin wraps around actin filament and thereby prevent myosin from binding with it and thus prevent contraction
C.The calcium ions are stored in the terminal cisternae of the sarcoplasmic reticulum.
The calcium stored in these cisternae of sarcoplasmic reticulum,releases during action potential causing muscles contraction. This calcium binds to troponin
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