Please select the best answer option for each Part. Part A. Dystrophin a) It int

Question

Please select the best answer option for each Part.

Part A. Dystrophin

a) It interacts with no other protein in muscle cells and functions in isolation.

b) It provides mechanical stability to the sarcolemma.

c) It was discovered first by Jerry Lewis in 1959, and he found the MDA as a result

d) It was missing from Lewis’ skeletal muscles thereby making him act uncoordinatedly in cinema

e) None are correct.

Part B. Which of the following statements concerning muscular dystrophy (MD) is true?

a) All MD are caused by defects in genes encoding components of dystrophin-glycoprotein complex
b) All MD are caused by mutations in the gene encoding dystrophin
c) All MD are caused by mutations in the gene encoding dysferlin
d) The cause of every MD is identified by positional cloning
e) None are true

Part C. Which of the following statements regarding Duchenne muscular dystrophy (DMD) is true?

a) It is caused by defects in a gene encoding a protein directly involved in energy metabolism.

b) It was first reported in the literature by physician Duchenne.

c) It was first discovered by Jerry Lewis in 1959, which prompted him to make the MDA.

d) DMD is caused by defects in the largest gene in the human genome.

e) None are true.

Explanation / Answer

Part A: DYSTROPHIN- B) It provides mechanical stability to sarcolemma

Part B: B) All MD are caused by mutations in the gene encoding dystrophin.

Part C: B) It was first reported in the literature by physician Duchenne

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