(15 points) The current theory around neuro-muscular activation of skeletal musc
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Question
(15 points) The current theory around neuro-muscular activation of skeletal muscle says that acetylcholine is the sole neurotransmitter that activates the contractile process. However research indicates that in some skeletal muscle there may be other neurotransmitters involved, if not in major activation events, but perhaps as a regulatory mechanism for activation. What might this/these regulatory transmitters be? Describe what might be the "new" theory for neuronal activation of muscular contraction using evidence from the literature. 1.Explanation / Answer
Glutamate is the neurotransmitter other than acetylcholine which is involved in nerve and muscle connection. Some times earlier only one neurotransmitter acetylcholine was considered in neuromuscular activation. The researches on glutamate shows a good response in nerve muscle activation. Glutamate is mainly found in brain. Glutamate activates the glutamate receptor in the brain for further action. NMDA (N-Methyl D-aspartate) is mainly a glutamate receptor. Glutamate is released at nerve ending and activates glutamate receptor. They have main role in central nervous system that is brain and spinal cord control and coordination. After the discovery of glutamate as muscle activation neurotransmitter other than acetylcholine, it opens the whole new field of new theory generation for these types of neurotransmitters.
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