3. To determine the mechanism of reabsorption of compound Y, scientists evaluate

Question

3. To determine the mechanism of reabsorption of compound Y, scientists evaluated ion concentrations in the peritubular capillaries. Here is what they found: Nat ionlperitubular capillary increase ionltubular lumen K+ decrease increase decrease When they pre-treated the patient with rotenone, an inhibitor of the electron transport chain in the mitochondria, the rate of absorption of compound Y looked like: Time Based on this information, propose a mechanism of transport for the reabsorption of Compound Y.

Explanation / Answer

Ans:

Based on the graph we can say that transport of compound Y is ATP mediated active trasport and independedent of concentration gradient. The reabsorption reached to peak from zero and then again down to zero. If the transport was dependant on concentration gradient, then the graph won't touch zero---> because Glomerulus would continue to excrete compound Y from blood to the tubular lumen, and it would maintain the concentration gradient and also reabsorption would continue at a saturated rate[ grah would not touch zero ].

But in this graph, reabsorption started from zero to peak and then to zero. It means that absorption was facilitated by ATP mediated active transport, as the electron transport chain was blocked in mitochondria by rotenone, ATP synthesis was blocked. As a result, ATP in the tubular cell depleted by transporting compound Y. And as a result of depleted ATP, active transport of compount Y stopped to zero.

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