QUESTION 14 1 pointsSave Answer Determine if the function is characteristic of T

Question

QUESTION 14 1 pointsSave Answer Determine if the function is characteristic of Type A or Type B intercalated cells or both. JActivity increases during alkalosis A. Type A Type B Both Secretes H+ into the lumen of the collecting Chloride shift occurs at the basolateral membrane. Contains high levels of CA. The H+-K+- ATPase is located on the apical duct. ?. Secretes K+ into the collecting duct lumen. QUESTION 15 1 pointsSave Answer What is the mechanism for HCO3 reabsorption in the proximal tubule? ???? acts as a buffer for H+, combining to make H2CO3 which is then pumped from the lumen through the Type A intercalated cells into the ECF CO2 diffuses into proximal tubule cells. Carbonic anhydrase converts CO2 and water to H+ and HCO3 then NHE pumps the H+ into the lumen of the collecting duct and the Na+-HC03-symports moves HCO3-into the ECF HC03 is pumped into the proximal tubule cells by Na+-????-Symports. An HCO3-leak channels then allows it to move down its concentration gradient into the ECF CO2 diffuses through both the apical and the basolateral membranes of the proximal tubule cells to the ECF, where CA converts CO2 and H20 into H+ and HCO3

Explanation / Answer

Renal bed has two types of intercalated cells

A ( alpha) type and B (beta) type.

Q14:ans

Activity increases during alkalosis : Type B [ renal bed secrets HCO3- and reabsorb H+ to compensate the alkalosis].

Secrets H+ into lumen of the collecting duct: Type A

Chloride shift occurs at the basolateral membrane : Type A cell

Contains high level of CA : Both has high level of CA ( carbonic anhydrase )[ this enzyme is need to produce bicrabonate from CO2 and water]

The H+-K+-ATPase is located on the apical membrane : Type A cell.

Secrets K+ into collecting lumen : Type A cells

Q15: Answer is SECOND option

CO2 diffuse into proximal tubule cells. Carbonic anhydrase converts CO2 and water to H+ and HCO-3 then NHE pumps the H+ into the lumen of the collecting duct and Na+-HCO-3 symports moves HCO-3 into ecf

Cell type Function secrets Reabsorbs                A type Secrets acid(H+) via apical H+- ATPase , and H+/K+ATPase Reabsorb HCO-3 via basolateral Cl-/HCO-3 exchager B type Secrets HCO-3 via specialized apical Cl-/HCO-3 exchager Reabsorb acid (H+) via basal H+-ATPase

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