Question Completion Status: QUESTION 3 Aldosteronism: A 50 yow was found to have

Question

Question Completion Status: QUESTION 3 Aldosteronism: A 50 yow was found to have a blood pressure of 180/105 mm Hg at the time of a routine physical examination. The patient complained of muscle weakness and occasional cramping. She did not exhibit mEq/L: +HCO3, 35 mEq/L. "Plasma pH was 7.45. Total exchangeable Nar was 50 mEa/kg and K+ was 28 mEa/kg. Aldosterone secretion rate was Plasma concentrations were *Nat, 145 mEq/L; *K+, 2.5 elevated. An adrenalectomy was performed removing an adenoma. At a subsequent visit, her plasma concentrations were Na+,142 mEq/L; K+, 4.5 mEq/L; HCO3, 26 mEq/L. Plasma pH was 7.4. Total exchangeable Na» was 41 mEq/L and K+ was 41 mEq/L. Her blood pressure was 13090 mm Hg, and her aldosterone secretion rate was normal. 1. Explain the patient's weakness and cramps by identifying a key electrolyte 2. What is the explanation of the high exchangeable Na and low plasma potassium concentration and exchangeable K+: by identifying a key hormone involved. 3. What is the condition based upon the plasma pH upon first presentation of the patient? 4. Which substance in the blood is changed in the condition to explain this pH status before surgery? 5. Why doesn't the patient retain enough Na+ and water to develop edema? More specifically what would have to change at the glomerulus in order to reduce the amount of filtrate getting to the proximal tubule where most sodium is reabsorbed? QUESTION 4

Explanation / Answer

1))potassium is the key electrolyte responsible for patient s weakness and cramps. In hyperaldosteronism there is retention of water and sodium amd loss of potassium hypokalemia results in muscle weakness amd cramps potassium efflux is reduced so weakness occurs and cramps occures resulting in fatigue.

2))high exchageable sodium increase s as aldosterone with help of renin increase s the blood pressure when it falls by icreasincr sodium ansorption increasing potassium exctreation.

3))plasma ph is raised and sodium concentration l are normal there is increased bicarbonate which proves there may be merabolic alkalosis which resulted fron increase in sofium amd decreased potassium as potassium concentration is decreased.

4))hco3 is raised which proves that ph is changed alkalosis is present and potassium is decreased

5))edema is not formed because of aldosteronism escape increase in sodium absorption in kidney occurs upoto a limit after which increase of aldosterone does not effect sodium reabsorption in presence of high level of aldosterone sodium e is exreated

Sodium retention can be reduced if gromerular filtrate is incresed and when osmotic tension is reduced in peritubilar capillaries and renin activity shoul be reduced.

4))

Related Questions

Navigate

• Browse (All)
• Browse Q
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.