Leukocyte adhesion deficiency (LAD) is a genetic defect that leads to recurrent

Question

Leukocyte adhesion deficiency (LAD) is a genetic defect that leads to recurrent infections in the tissue and severe problems with wound healing. LAD patients also develop severe gingivitis (infections and inflammation of the gums). In LAD, leukocyte migration into tissues is severely impaired. All of these problems can be traced back to a genetic defect. Of the genetic defects listed below, which is the most likely cause of LAD? A mutation that introduces a stop codon into a gene that encodes part of the LFA-1 molecule (leading to a truncated protein). O A defect in blood cell development that leads to very low numbers of monocytes, but normal numbers of other blood cells. A mutation in the promoter of the TNFa gene that leads to high TNFa expression in tissue. A mutation that increases the stability of the E-selectin ligand protein

Explanation / Answer

1))a mutation that introduce s a stop codon into a gene that encides part of lfa molecule leading to truncated protein mutation s in ITGB2 gene results in this disease the gene is responsible for formation of integrated proteins called b2 integrins the conteibute to immune responses mutations in these gene fails the b2 integrins as a result leucocytes cannot attatch to the pdotein and reach blood stream and partivipart in immune response

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