A patient with a slow growing tumor (? = 0.125 Gy-1, ?/? = 3 Gy, ? = 0.25 h) wil

Question

A patient with a slow growing tumor (? = 0.125 Gy-1, ?/? = 3 Gy, ? = 0.25 h) will be treated using 36 daily fractions of 2 Gy. The effectiveness of this treatment is maximized for the special case when each daily fraction is delivered in a very short time compared to the half-time for sublethal damage repair (i.e., ?). Find the change in the total treatment dose (in Gy) needed to correct for the effects of delivering each daily fraction in 30 minutes rather than in a “very short time” compared to ?.

Explanation / Answer

In this case we see very short time compared to the half time for sublethal damage repair,( more biological damage will be done in tissues with short T12 than in tissues with longer T12 values) by delivering 36 fraction of 2gy in 30minutes leads to more effective on the tumor cells because apoptotic cells decreased when the fraction delivery time increases, the prolonged irridation regime plays a predominant factor affecing cell response.

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