Dr. Merola mentioned a class of drugs that \'target\' the inflammatory cytokine

Question

Dr. Merola mentioned a class of drugs that 'target' the inflammatory cytokine TNFa. These drugs are part of a broader group of drugs called biologics. Biologics are simply drugs derived from a biological source. Many biologics used in immune therapy are proteins that interfere with the normal function of other proteins The biologics that target TNFa block its interaction with TNFa receptors. How might these drugs work to prevent psoriasis? (select two answers) O They prevent the expression of adhesion molecules on the surface of circulating leukocytes, this prevents leukocytes from migrating into inflamed tissue. They prevent the expression of adhesion molecules on the surface of endothelial cells; this They prevent sentinel cells from recognizing microbes with their innate immune receptors; this They prevent TNFa from acting directly on skin cells; this blocks the overgrowth of cells in the They prevent the production of TNFa in the tissue; this blocks inflammation at a very early step. prevents leukocytes from migrating into inflamed tissue. blocks inflammation at a very early step skin O

Explanation / Answer

b) They prevent the expression of adhesion molecules on the surface of endothelial cells; this prevents leukocytes from migrating into inflammed tissue.

d) They prevent TNFa from acting directly on skin cells ; this blocks the overgrowth of cells in the skin.

Psoriasis is an auto immune skin disease. The TNFalpha causes becomes responsible for overgrowth of skin cells if it acts with TNFalpha receptors in skin cells. The drugs that block TNFalpha interaction also prevents leukocytes from reaching the affected cells thereby preventing psoriasis from developing.

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