Please answer all questions and provide an explanation for the correct choices.

ID: 3515433 • Letter: P

Question

6. Considering Leptin, which of the statements is NOT correct?

1. Leptin is secreted by white adipose tissue.

2. Genetically obese and diabetic Ob/Ob mouse has a null mutation in leptin gene.

3. Leptin causes significant weight loss in obese human subjects.

4. Leptin regulates sensation of satiety.

5. Main target tissue for leptin is hypothalamus.

7. Considering insulin which statement is correct?

A. Insulin is synthesized by the b cells of pancreatic islets.

B. Insulin is synthesized as a large precursor and then proteolytically cut to form 2 peptide chains.

C. Formation of condensed insulin within the storage granules depends on presence of Zinc.

D. Insulin containing granules have a distinct morphological appearance.

1. A &C are correct

2. A, B&D are correct

3. All the above

4. None of above.

8. Correctly complete this sentence: Thyroxin……

1. deficiency causes an increase in basal metabolic rate of human subjects.

2. plays an important role in development of human brain.

3. interacts with G protein linked receptors on the cell surface.

4. is synthesized by the parathyroid gland. (FALSE! Because it's actually produced in the thyroid gland from tyrosine and iodine)

5. forms an active complex with calcitonin.

6)2)genetically obese and diabetic ob/ob mouse has a null mutation in the leptin gene

7)1) A and C are correct

8)2) plays an important role in development of human brain

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