Consider seven recessive genes, a, e, d, j, l, r and y. The seven loci are close

Question

Consider seven recessive genes, a, e, d, j, l, r and y. The seven loci are closely linked in the centromeric region of an autosome but their order is unknown. Six deletions are examined in an individual that is heterozygous for all seven genes. All six deletions resulted in pseudodominance of at least two genes, and two deletions spanned the region of the centromere.

Centromere included

in deletion

Determine the gene order

Deletion

Centromere included

in deletion

Genes exhibiting pseudodominance del 1 No e and j del 2 Yes a,l and r del 3 No a and d del 4 Yes e,l, and r del 5 No d and y del 6 No e and l

Explanation / Answer

Given:

Seven Recessive Genes are: a, e, d, j, l, r and y

The Gene Order would be ydarlej (it could be the other way around jelrady)

The center of the centromere is between l and r.

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