A scientist is studying drugs that are antagonists to Hormone X. Hormone X binds

Question

A scientist is studying drugs that are antagonists to Hormone X. Hormone X binds to a Receptor Y which is coupled with Gaq

Antagonist 1 binds 5x faster and unbinds 3 times slower than hormone X
Antagonist 2 binds 3x faster and unbinds 4 times faster than hormone X

For each of the following, circle whether there will be an INCREASE, DECREASE, or NO CHANGE when the antagonist is administered to a patient

PKA activity INCREASE DECREASE NO CHANGE PLC activity INCREASE DECREASE NO CHANGE Vasodilation INCREASE DECREASE NO CHANGE Blood Pressure INCREASE DECREASE NO CHANGE Intracellular Ca2+ of some cells INCREASE DECREASE NO CHANGE

Explanation / Answer

Antagonist 1: PLA activity decrease

Antagonist 2: PLA activity increase

Antagonist 1: PLC activity decrease

Antagonist 2: PLC activity increase

Antagonist 1: vasodilation decrease

Antagonist: increase vasodilation

Antagonist 1: Blood pressure increase

Antagonist 2: Blood pressure decrease

Antagonist 1: Decrease intracellular calcium ions of some cells

Antagonist 2: increase intracellular calcium ions of some cells

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