The rate at which mutations occur throughout a genome has been assayed for some

Question

The rate at which mutations occur throughout a genome has been assayed for some organisms. In some cases, sequences that map to the start of Okazaki fragments were shown to have increased levels of mutation, compared to the average genome-wide mutation rate. This is especially true if these regions are also regulatory sequences of DNA that have high affinity for their associated proteins which rapidly rebind their DNA sequences post-replication. Provide a model that accounts for the elevated mutation rate of these types of sequences.

Explanation / Answer

Mutations in intergenic, or non-coding, DAN tend to accumulate at a faster rate than mutations in DAN that is actively in use in the organism.

In general, the mutation rate in unicellular eukaryotes and bacteria is roughly 0.003 mutations per genome per cell generation. This means that a human genome accumulates around 64 new mutations per generation because each full generation involves a number of cell divisions to generate gametes. The highest per base pair per generation mutation rates are found in viruses, which can either have RNA or DNA genomes. DAN viruses have mutation rates between micro to nano mutations per base pair generation and RNA viruses have mutations rates between milli per base pair per generation.

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