For questions 45-49 choose the best answer from the following list. Answers may

Question

For questions 45-49 choose the best answer from the following list. Answers may be used once, more than once, or not at all. Each question has only one best answer. a Galpha() b.Galpha(s) c. Galpha(q) dAll of the above 45. inhibition of adenylate cyclase 46. inactivatod by spontaneous hydrolysis of GTP 47. PKA activation 48. Activation of PLA2 49. Calcium induced caleium release 1M S0. Coaverts arachidonic acid to some of its' bioactive metabolites a PLA2 d. CAM kinases e. cAMP 51. DIRECTLY precedes the binding of GTP to the G(alpha) subunit a. Agonist binding b. Antagonist binding Dissociation of GDP c. d. Effector activation e. Generation of second messengers 52. Mechanism to shut down any heterotrimeric G protein a. b. Desensitization of the ER to IP3 Pumping Cat+ into mitochondria d. e. Receptor mediated endocytosis All of the above 53. Which of the following are possible mechanisms used to turn off receptors with Galpha I subunits? a. Blocking capacitative Cat+ influx b. Catt/ATPase c. Change in RMP d. Reassociation of the regulatory and catalytic subunits of PKA e. Spontaneous hydrolysis of GTP .sp 54. Which of the following represent mechanisms to turn off heterotrimeric G-proteins containing a Galpha q subunit? a. Active pumping of calcium out of the cell b. movement of Ca++ into the endoplasmic reticulum c. movement of Cat+ into mitochondria d. all of the above e. a and b 55. What class of receptors was discussed with respect to the pathogenesis of cancer? a. receptor operated channels b. monomeric G-proteins c. heterotrimeric G-proteins d. tyrosine kinase receptors e. receptors with intrinsic enzymatic activity

Explanation / Answer

Galpha (i) - Inhibits adenylate cyclase

Galpha (s) - Activates adenylate cyclase

Galpha (q) - Activates phospholipase C

45. Gaplha (i)

46. All of the above

47. Galpha (s)

48. Galpha (q)

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