11. How does a H2 blocker prevent gastric secretion of HCI? a. It blocks the pri
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11. How does a H2 blocker prevent gastric secretion of HCI? a. It blocks the primary active transport of Hydrogen from parietal cells b. It prevents Histamine from binding to H2 receptors on parietal cells c. It blocks Histamine secretion from enterochromaffin like cells 2. Which of the following is NOT a function of pancreatic bicarbonate? a. It buffers gastric acid entering into the intestines b. It provides an alkaline pH for the intestinal and pancreatic enzymes c. It stimulates the secretion of pancreatic enzymes 13. Fat digestion would occur fastest in which of the following test tube. (the tubes indicate the ORIGINAL contents) a. Test tube 1: Originally contained vegetable oil, lipase and HCO3 (bicarbonate) b. Test tube 2: Originally contained vegetable oil, lipase, bile and HCO3 (bicarbonate) C. Test tube 3: Originally contained vegetable oil, lipase, bile and HCIExplanation / Answer
Q 11 H2 blockers act by inhibition of binding of histamine to H2 receptor on parietal cells.
Their action are fast as they block h2 receptor mediated decrease in the level of cAmp level lead to inhibition of H K Atpase pump... ....their effect is not as prominent as with proton pump inhibitor....
Vagus nerve release GRP which act on G cells they release gastrin, act on the ECL cells they released histamine and bind H2 receptor blok by H2 blocker like ranitidine.
Q12 pancreatic bicarbonate helps in both neutralisation of acid as well activation of pancreatic enzyme in alkaline pH which is maintained by HCL secretion.
So answer is C , Hco3- not have any role in secretion of pancreatic enzymes, this function is don by Cholecystokinin enzyme.
Q 13 answer is B test tube 2 , because it contain both lipase along with Hco3 help in lipase activation as well action is promoted at alkaline pH, also thei is present of Bile - it helps by emulsification of fats in to small droplets, and foem micells which help absorption of fats.
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