Exercise 2.2. Conditions Affecting Bony Matrix In order to perform its supportiv

Question

Exercise 2.2. Conditions Affecting Bony Matrix In order to perform its supportive and protective functions, bone must be both strong and flexible. As a type of connective tissue, its physical properties are determined by the chemical makeup of its extracellular matrix. Bony matrix is roughly 25% organic fibrous proteins, 50% inorganic mineral salts, and 25% water. The fibrous proteins provide bone with good tensile strength and flexibility while the mineral salts produce a tissue that is hard, but still relatively lightweight. Two medical conditions, osteoporosis and rickets, alter the makeup of bony matrix secreted by osteoblasts. Using the National Institutes of Health website (https://medlineplus.gov/healthtopics.html) research each of these conditions. In your own words, write a brief summary of each. How does each condition affect the makeup of bones? a. Osteoporosis Summary 1. b. Rickets Summary

Explanation / Answer

Ans:- Osteoporosis summary:- Osteoporisis is a disorder in which a loss of bone mass and strength leads to fructures it occurs mostly in post menopausal women in which estrogen deficiency likely is a key role. The bones becomes thinner which makes them more likely to break. Many people lose bone gradually over many years as it is asymptomatic. The condition Osteoporosis is not fully understood, in body normally old bones breaks and rebuilts a process called remodelling. At certain age the process of bone remodelling changes and new bone comes in a slower rate and hence this slowdown leads to a drop in the amount of bone normally body have.When bone loss becomes more severe, a condition occurs called osteoporosis.

Rickets Summary:- Rickets is a skeltal disorder of children caused by deficiency of vitamin D which leads to the softening and weakining of bones. The deficiency of vitamin D in the body makes it difficult to maintain proper calcium and phosphorus levels in bones, which can cause rickets. Rickets softens the growth plates at the ends of child's bones which causes skeletal deformalities example bowed legs and knock knees, thickened ankles and wrists, breastbone projection.The treatment of rickets focuses on increasing the patient's intake of calcium, phosphates, and vitamin D.

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