CASE #4 The parents of a 14 year old male brought their son to his pediatrician
ID: 3520748 • Letter: C
Question
CASE #4 The parents of a 14 year old male brought their son to his pediatrician because they thought it odd that he was wearing the same size clothes for the past few years. On examination his weight was in the I0h percentile and his height of 4 feet, 9 inches was below the 5th percentile for his age group. The following laboratory results were obtained: GH IGF-1 0.7 ng/mL (0.7-6.0) repeat analysis the following day 0.5ng/ml 112 mg/mL (152-540) Both parents of this child were relatively short (5'9" and 5'3"). Based on the laboratory results is this just a case of familial growth delay or is there evidence of a medical reason. Explain your answer. (1) 1. 2. State what endocrine organ secretes GH and describe the hypothalamic factors that control the secretion of growth hormone. (1.5)? 3. Since the initial level of growth hormone was borderline normal, a repeat analysis was done. Is it unusual for the GH values to be different in repeat samples? Explain your answer. (1.5) 4. Describe a challenge test that can be used to confirm the GH level in this case.Explanation / Answer
The GH or growth hormone and insulin growth factor IGF are responsible for the cell reproduction, division and regeneration. It's a mitogen that raises glucose levels in the body and also increase IGF-1 to stimulate growth of the body.
Anterior pituitary secreted growth hormone and a hypothalamic hormone called Growth hormone releasing hormone regulates the secretion of growth hormone.
No it's no unusual because the fluctuate in the blood according to the conditions of the body for example GH are usually increased after eating and sleeping.
A GH stimulation test can be ordered where in a stimulant is administered through IV. This stimulant is meant to increase the GH secretion. Several blood samples are taken on hourly basis
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