In a hemoglobin variant known as hemoglobin Kansas, an Asparaginein the beta cha

Question

In a hemoglobin variant known as hemoglobin Kansas, an Asparaginein the beta chain is replaced by a Threonine. This results in thedisruption of a hydrogen bond that normally stabilizes the R-stateof hemoglobin. Which statement is FALSE regarding the effect thisamino acid change has on the ability of hemoglobin Kansas to bindoxygen?

a. Inhemoglobin Kansas, there is an increase in the amount of R-stateand a decrease in the amount of T-state.

b. In hemoglobinKansas, there is a decrease in the amount of R-state and anincrease in the amount of T-state.

c. The R-state inhemoglobin Kansas is less stable than normal.

d. The presence ofless oxy-Hb in hemoglobin Kansas indicates this type of Hb has alower affinity for oxygen.

e. The p50 forhemoglobin Kansas is higher than normal.

Explanation / Answer

If there is a disruption of a hydrogen bond that normally stabilizes the R-state of hemoglobin, there is not likely to be and increase in the amount of R-state because of the instability of the hydrogen bond. The R-state would either slow down or remain constant.

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