Know the function of these cell types: chondroblasts (which arise from chondropr
ID: 3522362 • Letter: K
Question
Know the function of these cell types: chondroblasts (which arise from chondroprogenitors), chondrocytes, chondroclasts; osteoblasts (which arise from osteoprogenitors), BLCs, osteocytes, osteoclasts. Know the differentiation pathway for the cells of the osteogenic lineage (how does the structure of the cells reflect the function at various stages in the lifespan)? Are osteoclasts part of this lineage? How does the structure of an osteoblast, osteocyte and osteoclast reflect its function? How are cells of the osteoblast & chondroblast lineage related to fibroblasts?
Explanation / Answer
Chondroblast give rise to chondrocyte which form the cartilage.
Osteoblasts give rise to osteocytes which form bone cell.
Osteoclast resorbs bone and results in bone loss.
A chondroclast is a mature osteoclast which resorbs cartilage and leads to arthritis.
The osteogenic pathway is determined by mechanical induction of stem cell through physical tension .
The osteogenic stem cells differentiates to form osteoblast which forms bone matrix but cannot perform mitosis.
The osteoblast differentiates further into osteocytes which are spider like cells which maintain the bone matrix.
Osteoclasts are part of the macrophage lineage which are present on the surface of the bone .
Osteoblast cause bone formation by deposition into the bone matrix. During this they remain in cuboidal state. Other times they are in inactive state that is flattened shape.
Osteocytes maintain bone matrix by mineralisation. They have spider like cell process to maintain connection with osteoblasts and also to maintain the skeletal structure internally .
Osteoclast secrete digestive juices which corrode the bone. They are multinucleated cells which allow multi macrophage activity on a localised area of bone.
The osteoblast and chondroblast lineage are related to the fibroblast lineage because they all result from proliferation of mesenchymal stem cell.
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