The antibiotic valinomycin inhibits the majority of ATP production in the mitoch

Question

The antibiotic valinomycin inhibits the majority of ATP production in the mitochondria, but not the production of molecular water. Which of the following sentences best describes valinomycin’s actions?
A) It inhibits binding of NADH to Electron Transport System enzymes. B) It prevents pyruvate from entering the mitochondria. C) It uncouples ATP synthase molecules. D) It blocks Kreb’s cycle production The antibiotic valinomycin inhibits the majority of ATP production in the mitochondria, but not the production of molecular water. Which of the following sentences best describes valinomycin’s actions?
A) It inhibits binding of NADH to Electron Transport System enzymes. B) It prevents pyruvate from entering the mitochondria. C) It uncouples ATP synthase molecules. D) It blocks Kreb’s cycle production The antibiotic valinomycin inhibits the majority of ATP production in the mitochondria, but not the production of molecular water. Which of the following sentences best describes valinomycin’s actions?
A) It inhibits binding of NADH to Electron Transport System enzymes. B) It prevents pyruvate from entering the mitochondria. C) It uncouples ATP synthase molecules. D) It blocks Kreb’s cycle production

Explanation / Answer

The answer is C. The effect of valinomycin on mitochondria was first studied by McMurray and Begg who showed that the compound under certain circumstances both uncoupled respiration from phosphorylation and stimulated ATPase activity. It is highly selective for potassium ions . It functions as a potassium - specific transporter and facilitates the movements of potassium ions through lipid membranes down the electrochemical potential gradient. Valinomycin slows mitochondrial ATP synthesis without blocking electron transfer to O2.

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