1. Which proteins in the p53 pathway are expressed due to DNA damage? ( 2 answer

Question

1. Which proteins in the p53 pathway are expressed due to DNA damage? (2 answers)

a. p21
b. ATM
c. Puma
d. Mdm2
e. ATR
f. checkpoint kinase

2. Which of the following are transcription factors (proteins that turn on gene expression)? (3 answers)

a. E2F
b. Rb
c. Mad and Bu

d. Ras

e. Jun

f. Fos

Which of the following are important for pulling chromosomes to the poles of the cell?

E2F
Rb
Mad and BubRasJun Fos

Jun Fos

Which of the following are important for pulling chromosomes to the poles of the cell?

E2F
Rb
Mad and BubRasJun Fos

Explanation / Answer

1. The proteins that are expressed due to DNA damage are (b) ATM and (f) Checkpoint kinase.

The most important protein in case of p53 DNA damage response is ATM which further activates the Checkpoint kinase. This checkpoint kinase further amplifies the signal and helps to expand the number of proteins in order to control the DNA damage.

2. The three transcription factors are

(a) E2F - Family of transcription factors with most important one being E2F1

(e) Jun - The most important protein is c-Jun which acts as early response transcription factor

(f) Fos - Fos protein has a number of transcription factors like c-FOs, FosB, Fra-1 and Fra-2

3.

(d) Jun Fos are important for pulling chromosomes to the poles of the cells. c-Jun in combination with c-Fos helps to pull the chromosomes to the poles of the cells.

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