2.c please give me the multiple sequence alignment by using Clustal Omega. I don

Question

2.c please give me the multiple sequence alignment by using Clustal Omega. I don't know how to edit the sequences in correct format.

2. Multiple Sequence Alignment For this problem, the gap score P =-1 and scoring matrix s is shown as below. A C GT A 3 -3-13 C 3 3-3 G 1 3 33 T -3 1-33 Construct a multiple alignment of the four DNA sequences: X2 = CAGG X3 = CTGT X4 = ACAC a. Compute all pairwise alignment scores. b. Compute (by hand) the guide tree for these sequences based on the pairwise scores. C. Please use Clustal Omega to give the multiple sequence alignment. https://www.ebi.ac.uk/Tools/msa/clustalo/

Explanation / Answer

Aligning multiple sequences highlights areas of similarity which may be associated with specific features that have been more highly conserved than other regions. These regions in turn can help classify sequences or to inform experiment design.

Multiple sequence alignment is also an important step for phylogenetic analysis, which aims to model the substitutions that have occured over evolution and derive the evolutionary relationships between sequences.

Clustal Omega improves on ClustalW in a number of ways - alignment accuracy and improved scaling to many sequences are the main results.

There are two ways to use this service at EMBL-EBI. The first is interactively (default) and the second is by email. Using it interactively, the user must wait for the results to be displayed in the browser window. The email option means that the results will not be displayed in the browser window but instead a link to the results will be sent by email. The email option is the better one to take when submitting large amounts of data or a job that might take a long time to run.

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