I\'m doing my High School biology final on Progeria, and am wondering what type

Question

I'm doing my High School biology final on Progeria, and am wondering what type of mutation causes this disease.

I know that the LMNA gene codes for the "prelamin A" protein, and that protein contains a farnesyl group that is then not able to be removed (in the case of Progeria). The abnormal form (with the farnesyl still attached) of prelamin A is then called progerin, and attaches to the nuclear rim resulting in an abnormally formed cell nucleus, making mitosis impossible.

Is this a structural mutation? What sort of mutation is this?

Explanation / Answer

Hutchinson

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