2. Barbara has two brothers and a sister, all in good health. Barbara?s mother h
ID: 36142 • Letter: 2
Question
2. Barbara has two brothers and a sister, all in good health. Barbara?s mother has sickle cell anemia (a recessive condition). She knows that her uncle on her mother?s side also has sickle cell anemia, as does her paternal grandfather. On the other hand, her remaining grandparents, her father, one paternal aunt, and one maternal uncle are unaffected. a. Drawthe pedigree for this family, and deducethe genotypes of as many individuals as possible. b. What is the likelihood that Barbara will pass the allele for sickle cell anemia on to her children? c. What is the probability of Barbara?s parents having the children they do (that is, four children which are unaffected)? d. What is the probability of her parents having one or more of their four children who were affected?Explanation / Answer
b. There is 50% chances that Barbara will pass the allele.
c. 2:3
b. 1:3
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