CELL BIOLOGY What is transported in and out of the nucleus and how are things mo

Question

CELL BIOLOGY

What is transported in and out of the nucleus and how are things moved in and out of the nucleus?

For nucleus know the function of the following: nuclear import receptors, phenylalanine-glycine, NPC Proteins (in book and lecture notes)

Know the mechanisms for importing proteins into and out of the nucleus.

All proteins and events associated with Figure 12.12 and 12.13

Know the different membranes and compartments for the mitochondria and chloroplast.

For the mitochondria know the function of TOM complex, TIM complexes, SAM complex, OXA complex.

Know all of the events of importing proteins into the mitochondria.

Slides 40-46

Make sure you know the function of heat shock protein 70 (hsp70)

What is the function of the ER?

Include the Function of rough ER

Include the Function of smooth ER

Know the difference between   co-transport and post-transport

How signal sequences were first discovered (lecture on rough ER and microsomes)

Know what the SRP and SRP receptor is and their function in directing proteins into the rough ER.

What is a polyribosome and how is this involved with the rough ER?

Know the role of Sec61 in ER transport

Alberts.-.Molecular.Biology.Of.The.Cell.5th.Ed is the text

Explanation / Answer

The endoplasmic reticulum serves many general functions, including the facilitation of protein folding and the transport of synthesized proteins in sacs called cisternae.

Correct folding of newly-made proteins is made possible by several endoplasmic reticulum chaperone proteins, including protein disulfide isomerase (PDI), ERp29, the Hsp70 family member Grp78, calnexin, calreticulin, and the peptidylpropyl isomerase family. Only properly-folded proteins are transported from the rough ER to the Golgi complex.

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