You replace the normal GTP in a cell with a version that cannot be hydrolyzed. W

Question

You replace the normal GTP in a cell with a version that cannot be hydrolyzed. What do you predict would happen to microtubules as a result of this action? A Microtubules will tend to shrink. B. Microtubules will tend to grow. C. The diameter of the microtubule cylinder will be larger. D. The diameter of the microtubule cylinder will be smaller. E. Microtubules will cycle faster between growing and shrinking phases. F. Both B and C. G. Both A and D H. There will be no change in microtubule behavior.

Explanation / Answer

The answer is F. Both B and C.

The process of polymerization and depolymerization in microtubules depends upon GTP. When tubulin attaches to GTP, polymerization begins. When GTP is hydrolyzed to GDP, polymerization stops. GTP binds tightly to the tubulin molecules while GDP falls off the molecule easily. This leads to increase in growth of the microtubule and the diameter of the cylinder will be larger.

Hence, the answer is F.

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