Explain Please A mutation causing an addition or a deletion of one base pair res

Question

Explain Please

A mutation causing an addition or a deletion of one base pair resulted in the production of a nonfunctional mutant protein. The sequences of the normal and mutant proteins are given below.

Normal: Met - Leu - Ala - Thr - Gln

Mutant: Met - Leu - Ala - His - Pro - Ile - Glu - Ser - Thr - .....

Was this mutation cause by an insertion or a deletion?

Below, fill in the codons in the coding sequence of the mRNA that is translated into the mutant protein. If more than one codon is possible, just enter a single codon.

   NH2    Met Leu Ala His Pro Ile codons 5' AUG    UUG    ______    _____    ______    _______

Explanation / Answer

Answer

The mutation is due to Deletion. This deletion causes a shift in the codon where Threonine is read as Histidine resulting in the change in protein sequence.

Codons:

Met – AUG

Leu – UUG

Ala – GCG

His – CAU

Pro – CCG     

Ile - UUC

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