apling earning 1.0 The graph at the right shows the effect of oxygen pressure on
ID: 38401 • Letter: A
Question
apling earning 1.0 The graph at the right shows the effect of oxygen pressure on binding to hemoglobin under several different conditions. For each of the following six changes in conditions, select the shift that would occur in the binding curve. (Y is the fraction of 0.9 binding sites occupied). 0.7 0.6 The blood pH drops from 7.4 to 7.2 Select answer 0.5 0.4 0.3 The blood CO2 concentration increases Select answer 0.1 The concentration of 2,3-bisphosphoglycerate increases Select answer during acclimation to high altitude. An infant's fetal hemoglobin (HbF) is replaced by norma Select answer adult hemoglobin (HbA) Hemoglobin is isolated from red cells and stripped of Select answer 2,3-bisphosphoglycerate. 20 40 60 80 100 120 2 (torr)Explanation / Answer
1. B -> C
2. B -> C
3. B -> C
4. A -> B
5. B -> A
DISCUSSION
If B is baseline or "normal" Then these answers work -
A rightward shift indicates that the haemoglobin under study has a decreased affinity for oxygen. This makes it more difficult for haemoglobin to bind to oxygen (requiring a higher partial pressure of oxygen to achieve the same oxygen saturation), but it makes it easier for the haemoglobin to release oxygen bound to it. The effect of this rightward shift of the curve increases the partial pressure of oxygen in the tissues when it is most needed, such as during exercise, or haemorrhagic shock.
The causes of shift to right can be remembered using the mnemonic, "CADET, face Right!" for CO2,Acid, 2,3-DPG, Exercise and Temperature.
In contrast, the curve is shifted to the left by the opposite of these conditions. This leftward shift indicates that the haemoglobin under study has an increased affinity for oxygen so that haemoglobin binds oxygen more easily, but unloads it more reluctantly.
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