1.)What are two main distinctions between linkage and association mapping? 2.)Ho

Question

1.)What are two main distinctions between linkage and association mapping?

2.)How are markers used in QTL analysis chosen? What determines whether a marker will be useful in a mapping study?

3.)When creating a transgenic mouse by random insertion, the DNA is usually incorporated into where?

a. the sex chromosomes
b. liver and brain tissue
c. multiple sites throughout the genome
d. None of the above

4.)Swapping an inactivated allele for a gene of interest produces a ____ mouse while replacing a gene with another that has an altered function creates a ____ mouse.

                  A)              knockout, knockout

                  B)              knockout, gene targeted

                  C)              knockout, knockin

                  D)             gene targeted, knockin

Explanation / Answer

(1) When we are analysing physical segments of a genome that are associated with a set of given traits, we are talking about Linkage. On the other hand Association mapping is just the opposite way when we are looking for traits associated with physical segments of genome. So if we have a trait for a particular disease, can we associate that with differences among individuals in a population? So a linkage mapping we analyse the association between pieces of the DNA and a trait of interest. In Association mapping we track these differences in the disease traits among different individuals.

There are several advantages and disadvantages of using QTL markers as listed in the table below. Based on the needs and the weighing the pros n cons as listed below markers can be chosen. For detection of QTLs, a relatively sparse

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.