24) it turns out that the cellular prion protein, PrP^c, is not essential, and t

Question

24) it turns out that the cellular prion protein, PrP^c, is not essential, and transgenic mice have been created that are deleted for both alleles of the prion-encoding gene in 1992 (Bueler H. et al). These mice develop and behave normally, but show a number of mild phenotypic abnormalities. Drawing on your knowledge of the molecular pathology of prion disease, you expect these mice to . A) spontaneously develop a spongiform encephalopathy. B) still be susceptible to transmissible prion disease. C) be immune to transmissible prion disease.

Explanation / Answer

A) spontaneously develop a spongiform encephalopathy

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