QUESTIONS 17-19. The HIV envelope glycoprotein gp 120 is found at the surface of

Question

QUESTIONS 17-19. The HIV envelope glycoprotein gp 120 is found at the surface of the virion and specifically binds to CD4, a host-cell receptor present at the surface of some human white blood cells (macrophages, helper T cells). Binding and entry of the Human Immunodeficiency Virus (HIV) into cells absolutely requires the presence of CD4 on the host cell surface. Studies have shown that when human and animal cells from various tissues are genetically modified to express the human CD4 at the cell surface, the cells fully support viral entry, replication, and release of infectious HIV virions. 17) You expect human T cells with the CD8 protein (but not CD4) to be _. A) permissive for HIV B) susceptible for HIV C) both permissive and susceptible for HIV D) neither permissive nor susceptible for HIV E) impossible, since all human white blood cells have CD4. 18) Based on the studies mentioned here above. Human or animal cells genetically modified to produce the human CD4 protein at their surface are _ A) permissive for HIV, but not susceptible to HIV B) susceptible to HIV, but not permissive for HIV C) both permissive and susceptible to HIV D) neither permissive nor susceptible to HIV 19) Instead of carrying out a normal infection of cells, you artificially introduce the purified RNA genome of HIV (only RNA, no viral proteins) into a human helper T cell. You are told that the viral RNA cannot function directly as a mRNA but, instead, needs to be reverse transcribed and integrated into the host genome first. You would predict that . A) New HIV virus particles would be produced B) No new HIV virus particles would be produced

Explanation / Answer

17. D

18. C

19. B

Related Questions

Navigate

• Browse (All)
• Browse Q
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.