Which of the following statements comparing the targeting of a mitochondrial mat

Question

Which of the following statements comparing the targeting of a mitochondrial matrix protein to the targeting of a protein to the ER is/are correct? Choose all that apply.

-Insertion of proteins into both compartments takes advantage of an energy source in the form of an electrochemical gradient.

-Proteins destined for either compartment are likely to retain their amino terminal targeting signals.

-Proteins translocated into either compartment have an equal chance of ultimately being localized to the outside of the cell.

Explanation / Answer

Protein targeting is the biological mechanism where the protein is transported to the destination. Among the following the correct statements regarding targeting of a mitochondrial protein to ER are as follows:

-Proteins destined for either compartment require sequences of amino acids which serve as targeting signals.

-Proteins destined for either compartment are inserted into their respective compartments in an unfolded state.

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