A bar also serves food but it has only one table Groups which arrive to eat when
ID: 401604 • Letter: A
Question
A bar also serves food but it has only one table Groups which arrive to eat when the table is occupied, stay at the bar and wait Groups arrive to eat according to a Poisson process with an interarrival time of 90 minutes. The times it takes groups to be served (from the time that they are seated until they pay and leave) are independent and identically distributed variables with a mean of 1 hour. What is the steady-state fraction of the time that people are at the table? If the service times are exponentially distributed, what is Wq for this queueing system? If all the service times are exactly 1 hour, what is Wq for this queueing system? If the service times have an Erlang distribution with k = 10 and an expected value of 1 hour, 1 what is Wq for this queueing system?Explanation / Answer
If the drug is intended for chronic use, an estimate of the time it takes for a drug plasma concentration to reach steady state is required for regulatory labeling. Further, regulatory guidance for studies conducted in special populations or for assessing drug interaction may specify that the measurements of interest be obtained when drug concentrations have reached steady state.
Although regulatory guidances discuss the need to conduct certain types of studies while drug concentrations are at steady state, there is limited information on exactly how to determine that steady state has in fact been reached.
During any dosing interval at steady state, the amount of the drug lost from the body for a dosage form equals the amount of the drug introduced into the body from the dosage form. Quantification of such a situation is practically impossible, because it will take an infinite number of half-lives to reach steady state. Therefore, as Hauck et al. (1) characterized it,
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