Below is the germline DNA for the kappa light-chain gene in humans. The interven
ID: 40188 • Letter: B
Question
Below is the germline DNA for the kappa light-chain gene in humans. The intervening sequence between regions is denoted by "---".
---|??V1??|---|??V2??|---|??V3??|---|??V4??|---|??V5??|---|??Vn??|---//---|?J1?|---|?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
Below is the final functional kappa light-chain protein produced from this DNA in a mature B-cell.
|??V3??||?J2?||??C??|
Which of the following is the correct DNA arrangement after somatic recombination occurs in a mature B-cell?
a. ---|??V3??||?J2?||??C??|---
b. ---|??V1??|---|??V2??|---|??V3??|---|??V4??|---|??V5??|---|??Vn??|---//---|?J1?|---|?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
c. ---|??V1??|---|??V2??|---|??V3??||?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
d. ---|??V3??||?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
e. ---|??V1??|---|??V2??|---|??V3??|---|?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
Which of the following is the correct pre-mRNA arrangement in a mature B-cell?
a. ---|??V1??|---|??V2??|---|??V3??||?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
b. ---|??V3??||?J2?||??C??|---
c. ---|??V1??|---|??V2??|---|??V3??|---|??V4??|---|??V5??|---|??Vn??|---//---|?J1?|---|?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
d. ---|??V3??|---|?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
e. ---|??V3??||?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
Which of the following is the correct mRNA arrangement in a mature B-cell? For simplicity, the polyA tail has been omitted.
a. ---|??V1??|---|??V2??|---|??V3??|---|??V4??|---|??V5??|---|??Vn??|---//---|?J1?|---|?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
b. ---|??V3??||?J2?||??C??|---
c. ---|??V1??|---|??V2??|---|??V3??||?J2?|---|?J3?|---|?J4?|---|?J5?|---|??C??|---
d. ---|??V3??|---|?J2?|---|??C??|---
e. ---|??V1??|---|??V2??|---|??V3??||?J2?||??C??|---
Explanation / Answer
For Rearranged DNA from germline DNA: option C is right answer
For pre-mRNA: Option E is right answer
For mature mRNA: Option B is right answer
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