Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 220 GQ subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 30 ATP molecules to cAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer Lo at least two significant figures.

Explanation / Answer

220*30=6600 mol cAMP/s

6.6*103mol cAMP/s

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