The partial amino acid sequence of a wild-type protein is: . . . Arg-Met-Tyr-Thr

Question

The partial amino acid sequence of a wild-type protein is:
. . . Arg-Met-Tyr-Thr-Leu-Cys-Ser . . .

The same portion of the protein from a mutant has the sequence:
. . . Arg-Met-Tyr-Thr-Pro-Leu-Phe . . .

Using the same information as in the previous questions, give the possible sequence(s) of the wild-type DNA template strand.

Notation: A/G if the nucleotide could be either purine, T/C if it could be either pyrimidine, N if any nucleotide could occur at a site.

A. 3'-C-G-N-A-T-G-T-A-T-A-C-G-C-T-C-T-G-T-T-C-N-5'

B. 3'-A-G-A-A-T-G-T-A-T-A-C-G-C-T-C-T-G-T-T-C-N-5'

C. 3'-T-C-T/C-T-A-C-A-T-A-T-G-C-G-A-G-A-C-A-A-G-N-5'

D. 3'-G-C-N-T-A-C-A-T-A-T-G-C-G-A-G-A-C-A-A-G-N-5'

E. 3'-N-C-T-T-G-T-C-T-C-G-C-A-T-A-T-G-T-A-A-G-A-5'

A. 3'-C-G-N-A-T-G-T-A-T-A-C-G-C-T-C-T-G-T-T-C-N-5'

B. 3'-A-G-A-A-T-G-T-A-T-A-C-G-C-T-C-T-G-T-T-C-N-5'

C. 3'-T-C-T/C-T-A-C-A-T-A-T-G-C-G-A-G-A-C-A-A-G-N-5'

D. 3'-G-C-N-T-A-C-A-T-A-T-G-C-G-A-G-A-C-A-A-G-N-5'

E. 3'-N-C-T-T-G-T-C-T-C-G-C-A-T-A-T-G-T-A-A-G-A-5'

Explanation / Answer

The DNA temlete strand anticodons are read in 3 to 5 direction. Thus, the wild-type DNA template strand is,

B. 3'-A-G-A-A-T-G-T-A-T-A-C-G-C-T-C-T-G-T-T-C-N-5'

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