EXPLAIN your ANSWER Please answer if you know for sure!.. no rating for wrong an

Question

EXPLAIN your ANSWER Please

answer if you know for sure!.. no rating for wrong answer

ln the pedigree below, follow the expression of a paternally imprinted (autosomal) gene through the three generations. Part A Will the copy of the gene that originated in male l-2 be expressed or not expressed in the somatic cells of female II-2? NOTE: For this multipart question, you must submit ontime answers for ALL parts, in order to get ANY credit for the whole question. expressed not expressed Part B Will the copy of the gene that originated in male l-2 be expressed or not expressed in the germ cells of female II-2? NOTE: For this multipart question, you must submit ontime answers to ALL parts, in order to get ANY credit for the whole question. expressed not expressed

Explanation / Answer

Part A:

The autosomal dominant trait is passed from both father and mother equally. The affected children can be produced with 50%probability and unaffected children at 25%. Due to incomplete penetrance, the disease is not expressed in all affected individuals (heterozygous). The autosomal trait in somatic genes of father are not passed to next generation until, the mutation is a germline mutation. Therefore, the gene originated in I - 2 not expressed in somatic cells of female II - 2.

Hence option 'not expressed' is correct.

Part B:

The autosomal dominant trait expressed in father's germline cells is inherited to daughter since the mutation is in germline gene. Therefore, the gene of male I -2 is expressed in female II - 2.

The option 'expressed' is correct.

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