Proteins in a family of transcription factors (DNA binding molecules that activa

Question

Proteins in a family of transcription factors (DNA binding molecules that activate transcription) have 2 distinct domains: activation domain (AD) and DNA binding domain (DBD). These are not steroid hormone receptors since they do not require hormone binding to do their job. While studying a transcription factor (XP) you discover that if you break these two domains apart and attach them to two separate molecules (Y and Z) the transcription factor would still function as long as Y and Z bind to each other.

Which of the following would probably be true about this system? Explain each briefly. (8)

A.The AD and DBD cannot truly be considered

Explanation / Answer

A. The active domain and DNA binding domain are required for binding of transcription factors and to continue to the transcription process. Hence, the given statement is false.

B. For the transcription factor XP to bind to two seperate molecules Y and Z when the Z is mutated, the XP can no longer bind to Y and DBD. This results in inefficient binding of Z:XP-DBD to DNA. Hence, the given statement is true.

C. The transcription factor XP may have 3 dimensional structure like that of other transcirptional factors in the family therefore, it is able to recrute Y and Z domain. Hence the given statement is true.

D. The transcription factor XP may have some other mechanism unlike the transcription factors in this family and hence, it may work in alternate manner. Therefore, the given statement is false.

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