5) Below is a schematic representation of one VNTR studied in 20 individuals. Si

Question

5) Below is a schematic representation of one VNTR studied in 20 individuals. Since it is a single locus, each person should have two bands , one for each of the two homologous chromosomes. There are five different size bands (labeled A-E for convenience) see in this sample:

Assuming this small sample is presentative of the population, what are the frequencies of each fragment in the population?

A_______ B________ C________ D________ E_________

There is a crime committed and DNA evidence shows bands A and E. A suspect is tested and found to have the same two bands. He could be the criminal, but he could also be some poor schmuck in the wrong place at the wrong time. What is the chance that a random individual from this population would have exactly those two bands? Would you convict the suspect based on this evidence?

Explanation / Answer

5) Below is a schematic representation of one VNTR studied in 20 individuals. Since it is a single locus, each person should have two bands , one for each of the two homologous chromosomes. There are five different size bands (labeled A-E for convenience) see in this sample:

Genetic map is a representation of the relative position of genes on a chromosome based on the frequency of recombination between two DNA segments at meiosis. ( During meiosis I, two homologous chromosomes can pair and undergo recombination, which results in equal exchange of genetic material between the two chromosomes and produces recombinant chromosomes in the gametes). If the distance between the two genes increases, the probability of recombinational event occurance between them increases and will be separated during meosis I. Variable number tandem repeats (VNTRs) are highly polymorphic because of presence of variable numbers of tandem repeats of a short DNA sequence that have been shown to be inherited in a Mendelian codominant fashion. These stretches of repeats are found throughout the human genome and are often polymorphic, the number of repeats at any particular locus varies. The exact number of repeats in a person's two allelles can be measured at any particular repeat locus. Determination of allele pattern in haplotypes.

The measurement of recombination frequency is referred as genetic linkage analysis based on the use of genetic markers as VNTR, STR. The frequency is expressed in centimorgans (cM) where 1cM equals a recombination frequency of 1%

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