Indicate true (T) and false (F) statements below regarding the interaction of ce

Question

Indicate true (T) and false (F) statements below regarding the interaction of cells with the extracellular matrix using matrix receptors. Your answer would be a four-letter string composed of letters T and F only, e.g. TFTT.
( ) Integrins are the only known matrix receptors in animal cells.
( ) Integrins can transmit signals in both directions across the membrane; that is, both outside-in and inside-out.
( ) Tension can increase the binding affinity of an integrin for its intracellular and extracellular ligands.
( ) Integrins can convert molecular signals into mechanical ones.

Explanation / Answer

(F) Integrins are the only known matrix receptors in animal cells.

(T) Integrins can transmit signals in both directions across the membrane; that is, both outside-in and inside-out.

(T) Tension can increase the binding affinity of an integrin for its intracellular and extracellular ligands.

(T) Integrins can convert molecular signals into mechanical ones.

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