6. A. Please describe how the cytoskeleton plays a role in chromosome segregatio

Question

6. A. Please describe how the cytoskeleton plays a role in chromosome segregation during mitosis.

B. Please describe how the cytoskeleton plays a role in cytokinesis.

C. You have found an unlabeled bottle which you believe contains either nocodazole (a drug which inhibits microtubule polymerization) or cytochalasin D (a drug which destabilizes actin filaments). To identify which drug it is, you add an aliquot to a culture of cells. You find that under treatment with this drug, cells are able to undergo mitosis, but a binucleate cell (a cell containing two nuclei) is generated. Which drug is in the bottle? Please provide a reason for your prediction.

Explanation / Answer

. (a). The cytoskeleton provides cell shape, cell motility and also motility of organelles. Within the cytoplasm we can found three types of filaments namely microfilaments, microtubules, and intermediate filaments.

Microtubules are the hollow filaments, having a diameter of 20-25 nm. They are composed of a protein called

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