5. (10 pts.) Nonsense-mediated mRNA decay (NMD) s normally thought to promote th

Question

5. (10 pts.) Nonsense-mediated mRNA decay (NMD) s normally thought to promote the accelerated turnover of mutant mRNAs carrying premature termination codons (PTCs). However, it was recently found that the half-lives of about 10% of normal human mRNAs are also regulated by NMD. How was this percentage determined experimentally? What features might these mRNAs have to make them subject to NMD regulation? Briefly review the way that the NMD pathway normally works in the degradation of mutant mRNAs with PTCs and then propose a hypothesis that could reasonably explain how the half-life of a normal mRNAs is regulated by NMD.

Explanation / Answer

The percentage of normal human mRNAs are regulated by Nonsense-mediated mRNA decay (NMD) is determined when NMD triggered the premature termination.

The mRNA decay mechanism seves to regulate the cell of trascripts that do nto ahve complete open reading frames. Such transcripts arise from genes, in which an error in trasncription gives rise to premature nonsense condon or termination.

In brief, NMD is activated by premature translation termination that distinguish the events of normal termination.

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