Case 0123456789 Individual 1 gaacgaccat Individual 1 gaacgaccat Individual 1 gaa

Question

Case 0123456789

Individual 1 gaacgaccat

Individual 1 gaacgaccat

Individual 1 gaacgaccat

Individual 1 gaacgaccat

Individual 1 gaacgacgat

Control

Individual 1 gatcgacgaa

Individual 1 gatcgacgaa

Individual 1 gatcgacgat

Individual 1 gatcgacgaa

Individual 1 gttcgacgaa

5.1. Which SNP is strongly linked to the disorder?

a. position 2

b. position 3

c. position 4

d. position 8

e. position 9

5.2. You write up a paper describing these two groups as two new species and the paper comes back rejected because the reviewers say that you have

Explanation / Answer

5.1) Answer should be (d) Position 8.

5.2) Answer is (b) You go out and collect more individuals from Case and Control groups and analyze them in addition to the original data.

Making arguments would not solve the problem, so it is better to describe the two groups as two new species and obtain better results.

5.3) Answer is (c) involves alleles of genes with slight effect that are found in low frequency

The main focus was on high frequency genes that have less effect on common diseases.

5.4) Answer is (a)

He concentrated more on high frequency genes that have less effect on common diseases. But in fact, several genes are involved in developing diseases.

5.5) Answer is (e)

If different organisms of same species have different SNPs, then the SNPs do not restrict mating individually. They may have large amount of gene flow. If they freely mating then they cannot be genetically isolated.

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